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Malek, HA et al (2015)

Simply stated, a junctional melanocytic proliferation synchronously migrates across the dermal-epidermal junction and establishes a dermal component over a lateral dimension that is equal to that of the original epidermal component

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PIA and carbachol may cause a NCE by inhibiting the activity of adenylyl cyclases that were augmented by GCGR-stimulation by retatrutide